Silodosin

Silodosin (trade names Rapaflo (USA), Silodyx (Europe and South Africa), Rapilif (India), Silodal (India), Urief (Japan), Urorec (Russia)) is a medication for the symptomatic treatment of benign prostatic hyperplasia. It acts as an α1-adrenoceptor antagonist with high uroselectivity (selectivity for the prostate).

Pharmacology

Since silodosin has high affinity for the α1A adrenergic receptor, it causes practically no orthostatic hypotension (in contrast to other α1 blockers). On the other side, the high selectivity seems to be the cause of silodosin's typical side effect of loss of seminal emission.

As α1A adrenoceptor antagonists are being investigated as a means to male birth control due to their ability to inhibit ejaculation but not orgasm, a trial with 15 male volunteers was conducted. While silodosin was completely efficacious in preventing the release of semen in all subjects, 12 out of the 15 patients reported mild discomfort upon orgasm. The men also reported the psychosexual side effect of being strongly dissatisfied by their lack of ejaculation.

Product Description  

[English Name] silodosin

[Test Method]HPLC

[Purity]≥99%

[CAS No.] 160970-54-7

[Mol. Formula]C25H32F3N3O4

[Purity]> 99% by HPLC

[Packaging] 1g,5g,10g,100g...

Package and quantity according to customer's detail requirement

[Remark] In stock, customized for large scale.

Specifications:

Product Name	silodosin pharmaceutical intermediate
Supplier	N	Specification	99% min
Test Method	HPLC	Odor	Characteristic
Specific Rotation	-17-12°	Loss on drying	0.05%
Appearance	white Crystalline powder	CAS NO.	160970-54-7
Molecular Weight	495.53	Molecular Formula	C25H32F3N3O4
Residue on Igniton	0.07%	Heavy Metals	Confroms
Assay	99.63%	Related substances	0.15%
E.Coli	Negative	S.Aureus	Negative
Salmonella	Negative	Pesticides	Negative
Certificate	ISO9001,GMP
Functions	1 silodosin Got a good solve the curative effect of dysuria, also reduced the incidence of hypotension and other adverse reactions. 2 silodosin can reduce peripheral vascular resistance in other parts of the body to the body of the systolic blood pressure and diastolic pressure is lower
Shelf life	2 years	Package	25kg/fiber drum
Storage	Store in cool and dry places. Keep away from strong light.

Packaging & Shipping:

[Storage] Stored in a clean, cool and dry area; keep away from strong, direct light.

[Shelf Life] 2 years when properly stored.

[Packing]

Inner double plastic bags--25kg/Fiber drum (35*35*53cm, GW: 28kg, NW: 25kg, 0.06CBM);

Inner double plastic bags--5kg/Aluminum foil bag (GW: 6.5kg, NW: 5kg);

Inner double plastic bags--1kg/Aluminum foil bag (GW: 1.5kg, NW: 1kg).

[Delivery] 5 working days after payment.

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Notice: This product is only suitable for laboratory use, or the use of animals. It can not be used directly on the human body