Halofuginone

Halofuginone is a coccidiostat used in veterinary medicine. It is a synthetic halogenated derivative of febrifugine, a natural quinazolinone alkaloid which can be found in the Chinese herb Dichroa febrifuga (Chang Shan). Collgard Biopharmaceuticals is developing halofuginone for the treatment of scleroderma and it has received orphan drug designation from the U.S. Food and Drug Administration.

Halofuginone inhibits the development of T helper 17 cells, immune cells that play an important role in autoimmune disease, but it does not affect other kinds of T cells which are involved in normal immune function. Halofuginone therefore has potential for the treatment of autoimmune disorders.

Halofuginone is also an inhibitor of collagen type I gene expression and as a consequence it may inhibit tumor cell growth. Halofuginone exerts its effects by acting as a high affinity inhibitor of the enzyme Glutamyl-Prolyl tRNA synthetase. Inhibition of prolyl tRNA charging leads to the accumulation of uncharged prolyl tRNAs, which serve as a signal to initiate the amino acid starvation response, which in turn exerts anti-inflammatory and anti-fibrotic effects.

Details:

Formula

C16H17BrClN3O3

Molecular weight

414.68

EINECS

CAS RN

55837-20-2

CAS Name

7-bromo-6-chloro-3-(3-((2S,3R)-3-hydroxypiperidin-2-yl)-2-oxopropyl)quinazolin-4(3H)-one

Halofuginone Hydrochloride

Synonyms

Halofuginone; Tempostatin; RU 19110; RU19110; RU-19110

rel-7-Bromo-6-chloro-3-[3-[(2R,3S)-3-hydroxy-2-piperidinyl]-2-oxopropyl]-4(3H)-quinazolinone Hydrochloride; 7-Bromo-6-chlorofebrifugine Hydrochloride; HAL;

Minimum assay

>98%

Form

Off-White Solid

Solubility

Application

Halofuginone is a halogenated derivative of Febrifugine (F228500). Halofuginone is used as an antiprotozoal.

Melting point ca.

247-249°C (dec.)

Boiling point ca.

595.8 °C at 760 mmHg

Density g/cm3 (20°C)

1.73 g/cm3

Refractive index

Flash point

314.1 °C

Stability

Packaging

Storage

Dry, dark and at 0 - 4 C for short term

-20 C for long term

Specification:

Product Name	dichroa root extract
Appearance Form	brown fine powder
Active Ingredient	dichroine
Specifications	5% 10%
Mesh	80mesh
Loss on Drying	≤8%
Part used	root
Test method	HPLC
Extract Solvent	Ethanol
Yeast & Mold	≤100cfu/g
E.Coil	Negative
Salmonella	Negative

Function:

1. Halofuginone not only as a type I collagen synthesis inhibitor, has begun to apply the specific clinical, but also as an inhibitor of tumor growth and metastasis.

2.The anti-cancer mechanism that halofuginone can inhibit the excessive collagen production, which can inhibit tumor growth in a series of crucial cell activity, including blood vessel formation, cell reproduction and migration.

3.For the stage of disease at 23 to 28 days of age developed characteristics and physiological characteristics.

3.the variety of active factors by adding sea buckthorn seabuckthorn extract the active ingredients, protect and accelerate the repair of gastrointestinal mucosa of the herbs, rich in active ingredients which SOD, the content of ginseng 4 times, after 30 days fatten lay a solid foundation.

Application:

1. Medicine

 2. Health & Daily Chemicals

 3. Food & Animal feed

OEM Service

Package & Storage :

Packaging Detail	0.5kgs/Al-Bottle 1.0kgs/Al- Bottle 2.0kgs/Al- Bottle 5.0 kgs/Al-Bottle 25.0 kgs/drum or upon customers' request.
Storage	Store in a well-closed container away from moisture
Shelf Life	2 years if sealed and store away from direct sun light.
Delivery Detail	within 3 days after get the payment

Products picture:

Package picture:

factory picture:

Shipping terms:

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v Sea shipping for quantity over 500KG; 

v And air shipping is available for 50KG above;

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Notice: This product is only suitable for laboratory use, or the use of animals. It can not be used directly on the human body