MMI

Methimazole (also known as Tapazole or Thiamazole or MMI) is an antithyroid drug, and part of the thioamide group. Like its counterpart propylthiouracil, a major side effect of treatment is agranulocytosis.

Indications

Methimazole is a drug used to treat hyperthyroidism, a condition that occurs when the thyroid gland begins to produce an excess of thyroid hormone. The drug may also be taken before thyroid surgery to lower thyroid hormone levels and minimize the effects of thyroid manipulation. Additionally, methimazole is used in the veterinary setting to treat hyperthyroidism in cats.

Mechanism of action

Methimazole inhibits the enzyme thyroperoxidase, which normally acts in thyroid hormone synthesis by oxidizing the anion iodide (I−) to iodine (I2), hypoiodous acid (HOI), enzyme linked hypoiodate (EOI) facilitating iodine's addition to tyrosine residues on the hormone precursor thyroglobulin, a necessary step in the synthesis of triiodothyronine (T3) and thyroxine (T4).

It does not inhibit the action of the sodium-dependent iodide transporter located on follicular cells' basolateral membranes. Inhibition of this step requires competitive inhibitors such as perchlorate and thiocyanate.

It acts at CXCL10.

Introduction: 

Name: Methimazole;Thiamazol

CAS No.: 60-56-0

Molecular Formula: C4H6N2S

Molecular Weight: 114.16

Specification:

Property: White crystalline powder

Melting Point: 140-145°C

Assay: 99%

Solubility: Freely soluble in water, slightly soluble in ether

Package: 25kg/drum

Usage: Anti-thyroid drug

Specifications：

Items	Specifications	Results
Appearance	white or almost white crystalline powder	Complies
Identification	A,B in pass	Complies
Melting Point	143 - 146 °C	144.5-145°C
Ordinary impurities	≤ 0.1 %	Not found
Selenium	≤0.003 %	In pass
Loss on drying	≤0.5 %	0.39%
Residue on ignition	≤ 0. 1 %	0.05%
Assay	98.0 ~ 101.0 %	99.62%
Conclusion	Complies with USP34

Packaging & Shipping：

25kg carton drum (32cm*58cm)or 1kg foil bag (10cm*15cm) or by request of clients

Transit could be DHL,UPS,TNT,EMS,Fedex,and so on.

For mass orders, it will be delivered by air or sea.

Depending on your location, please allow 1-5 business days for your order to arrive.

For small order, please expect 3-7 days by UPS DHL EMS.

For mass order, please allow 5-8 days by Air, 15-30 days by Sea.

my contact infomation is: 

Email: cloris_2016@tuskwei.com or

bettytuskwei@yahoo.com

Skype: betty_3451

Website: http://www.tuskwei.net/

Notice: This product is only suitable for laboratory use, or the use of animals. It can not be used directly on the human body