Betamethasone is a steroid medication. It is used for a number of diseases including rheumatic disorders such as rheumatoid arthritis and systemic lupus erythematosus, skin diseases such as dermatitis and psoriasis, allergic conditions such as asthma and angioedema, preterm labor to speed the development of the baby, Crohn's disease, cancers such as leukemia, and along with fludrocortisone for adrenocortical insufficiency, among others. It can be taken by mouth, injected into a muscle, or applied as a cream. When given by injection, anti-inflammatory effects begin in around two hours and last for seven days.
Betamethasone was approved for medical use in the United States in 1961. The cream is on the WHO Model List of Essential Medicines, the most important medications needed in a basic health system. It is available as a generic medication. In the United States the pills and injectable solution are expensive while the cream is not.
Medical uses
Betamethasone is a corticosteroid that is available as pill, by injection, and as a cream.
It is used as a topical cream to relieve skin irritation, such as itching and flaking from eczema. It is used as a treatment for local psoriasis, as betamethasone dipropionate and salicylic acid, or as the combination calcipotriol/betamethasone dipropionate. Betamethasone sodium phosphate is used orally and via injection with the same indications as other steroids. Many betamethasone-based pharmaceuticals include the steroid as the valerate ester.
In a randomized controlled trial betamethasone was shown to reduce some of the ataxia symptoms associated with ataxia telangiectasia (A-T) by 28-31%.
Betamethasone is also used to stimulate fetal lung maturation (to prevent IRDS), and to decrease the incidence and mortality from intracranial hemorrhage in premature infants.
A cream with 0.05% betamethasone appears effective in treating phimosis in boys, and often averts the need for circumcision. It has replaced circumcision as the preferred treatment method for some physicians in the British National Health Service.
Product Description:
Notice: This product is only suitable for laboratory use, or the use of animals. It can not be used directly on the human body
CAS Number:
378-44-9
Name:Betamethasone
Formula:C22H29FO5
Molecular Weight:434.50
Synonyms:
Celestene;Prestwick_703;9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one;Rinderon A;Cidoten;beta-Methasone alcohol;Betamethazone;Bedifos;Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17, 21-trihydroxy-16-methyl-, (11.beta.,16.beta.)-;9.alpha.-Fluoro-16.beta.-methylprednisolone;Desacort-beta;Betsolan;Sch 4831;.beta.-Methasone alcohol;Pregna-1,4-diene-3,20-dione,9-fluoro-11,17,- 21-trihydroxy-16-methyl-,(11a,16a)-;Becort;Betacortril;Prednisolone, 9-fluoro-16beta-methyl-;Betamamallet;Betamethasone (JP14/USP);9-alpha-Fluoro-16-beta-methylprednisolone;Betafluorene;9-Fluoro-11-beta,17,21-trihydroxy-16-beta-methylpregna-1,4-diene-3,20-dione;Betapredol;Visubeta;
EINECS:206-825-4
Density:1.32 g/cm3
Melting Point:235-237 °C
Boiling Point:568.2 °C at 760 mmHg
Flash Point:297.5 °C
Appearance:white to off-white solid
Specifications:
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| ITEMS | SPECIFICATIONS | RESULTS |
| Appearance |
A white to almost white,odorless, crystalline powder
| Conforms |
| Identification | Complies with the stanard | Conforms |
| Loss on drying | ≤0.5% | 0.08 % |
| Residue on Ignition | ≤0.3% | 0.3% |
| Specific on rotation | +118~ +126. | + 123.4 ° |
| Melting point | 50 ℃ ~ 60 ℃ | 50 ℃ ~ 60 ℃ |
| Sulphate ash | ≤0.1% | 0.05% |
| Heavy metals | ≤ 20 ppm | < 20ppm |
| Related substance |
Total impurity ≤2.0%
Single impurity ≤.0%
|
0.41%
0.12%
|
| Methanol | ≤ 3000 ppm | Conforms |
| Ethylacetate | ≤ 3000 ppm | Conforms |
| DMF | ≤ 3000 ppm | Conforms |
| Acetone | ≤ 3000 ppm | Conforms |
| Dichlormethane | ≤ 3000 ppm | Conforms |
| Assay | 97.0~103.0% | 100.0 % |
| Conclusiion | This product complied with the standard of EP 6.0 | |
Package:
1kg,2kg,5kg/Aluminum Bag or small package as customer's requirement;
10kg,15kg,25kg/Drum,with food grade plastic bag inside.
Storage:
Store in a cool dry area.Keep Away from strong direct light.
Medical Use:
Betamethasone is mainly used for anti-inflammatory and anti-allergic. Suitable for rheumatoid arthritis and various skin diseases. Role with betamethasone, dexamethasone, its anti-inflammatory effects than dexamethasone, triamcinolone, hydrocortisone strong, with few side effects.
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Notice: This product is only suitable for laboratory use, or the use of animals. It can not be used directly on the human body
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