Rivaroxaban

Rivaroxaban (BAY 59-7939) is an oral anticoagulant invented and manufactured by Bayer;in a number of countries it is marketed as Xarelto. In the United States, it is marketed by Janssen Pharmaceutica. It is the first available orally active direct factor Xa inhibitor. Rivaroxaban is well absorbed from the gut and maximum inhibition of factor Xa occurs four hours after a dose. The effects last approximately 8–12 hours, but factor Xa activity does not return to normal within 24 hours so once-daily dosing is possible.

Medical uses

In those with non-valvular atrial fibrillation it appears to be as effective as warfarin in preventing nonhemorrhagic strokes and embolic events. Rivaroxaban is associated with lower rates of serious and fatal bleeding events than warfarin though rivaroxaban is associated with higher rates of bleeding in the gastrointestinal tract.

Details

CAS Number:366789-02-8

Name:2-Thiophenecarboxamide,5-chloro-N-[[(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-

Superlist Name:Rivaroxaban

Formula:C19H18ClN3O5S

Molecular Weight:435.88

Synonyms:5-Chloro-N-[[(S)-3-(4-(3-oxomorpholin-4-yl)phenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl]-thiophene-2-carboxamide;BAY 59-7939;Xarelto;

Density:1.46 g/cm3

Boiling Point:732.609 °C at 760 mmHg

Flash Point:396.868 °C

Specifications:

Items	Standard	Results
Appearance	White or almost white powder	White powder
Melting point	229~ 234℃	230.0~231.5℃
Residue on ignition	NMT0.1%	0.03%
Related substances	Any other impurity: NMT0.2% Total of impurity: NMT0.5 %	0.1%  0.19%
Loss on drying	NMT1.0%	0.13%
Heavy metal	NMT20ppm	Conforms
Purity	More than 99.50%	99.81%
Conclusion: The results show that the product complies with  the Enterprise standard.

Introduction:

Antithrombotic drugs

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Delivery:

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Notice: This product is only suitable for laboratory use, or the use of animals. It can not be used directly on the human body