Artesunate

Artesunate (AS) is a medication used to treat malaria. It is water-soluble and may therefore be given by injection. It is a semi-synthetic derivative of artemisinin.

It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system.

Name: Artesunate

CAS No.: 88495-63-0

Molecular Weight: 384.42082g/mol

Molecular Formula: C19H28O8

XLogP3-AA: 2.5

H-Bond Donor: 1

H-Bond Acceptor: 8

Melting Point: 132-1350°C

Surface Tension: 51.4 dyne/cm

Density: 1.31 g/cm3

Flash Point: 173.5 °C

Enthalpy of Vaporization: 84.4 kJ/mol

Boiling Point: 502.1 °C at 760 mmHg

Vapour Pressure: 1.92E-11 mmHg at 25°C

Product Categories: Active Pharmaceutical Ingredients;Natural Plant Extract;Intermediates & Fine Chemicals;Pharmaceuticals

Specifications:

tem	Specification	Result
Physical Property
Appearance	White crystal powder	Conforms
Odour	Characteristic	Conforms
Mesh Size	100% through 80% mesh size	Conforms
General Analysis
Identification  artemisinin Loss on Drying	Identical to R.S. sample 98% <5.0%c	Conforms 98.01%  3.22%
Ash	≤5.0%	3.37%
Contaminants
Pesticides Residue	Meet USP32<561>	Conforms
Lead(Pb)	≤3.0mg/kg	2.1
Arsenic(As)	≤2.0mg/kg	1.9
Cadmium(Cd)	≤1.0mg/kg	0.7
Mercury(Hg)	≤0.1mg/kg	0.07

Function:

1. With function of controlling of vivax malaria and falciparum malaria symptom, as

well as treatment of chloroquine-resistant strain of insect.

2. With function of oxidant. artemisinin is reduced by catalase,dithiothreitol and

alpha tocopherol.

3. With the function of antibacterial, artemisinin has anti-influenza virus effect.

4. With the function of anti-parasite, artemisinin on the role of anti-schistosomiasis

and leptospirosis.

Application:

1.Artesunate is an antimalarial agent. It is a water-soluble hemisuccinate derivative of dihydroartemisinin.

2.Artemisinin is a sesquiterpene lactone isolated from Artemisia annua, a herb that has traditionally been used in China for the treatment of malaria.

3.Artesunate and its active metabolite dihydroartemisinin are potent blood schizonticides, active against the ring stage of the parasite.

4.Artesunate is ideal for the treatment of severe malaria, including cerebral malaria. It is also active against chloroquine and mefloquine resistant strains of P. falciparum.

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Notice: This product is only suitable for laboratory use, or the use of animals. It can not be used directly on the human body