2016年10月10日星期一

Artesunate




Artesunate (AS) is a medication used to treat malaria. It is water-soluble and may therefore be given by injection. It is a semi-synthetic derivative of artemisinin.

It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system.

Name: Artesunate
CAS No.: 88495-63-0
Molecular Weight: 384.42082g/mol
Molecular Formula: C19H28O8
XLogP3-AA: 2.5
H-Bond Donor: 1
H-Bond Acceptor: 8
Melting Point: 132-1350°C
Surface Tension: 51.4 dyne/cm
Density: 1.31 g/cm3
Flash Point: 173.5 °C
Enthalpy of Vaporization: 84.4 kJ/mol
Boiling Point: 502.1 °C at 760 mmHg
Vapour Pressure: 1.92E-11 mmHg at 25°C
Product Categories: Active Pharmaceutical Ingredients;Natural Plant Extract;Intermediates & Fine Chemicals;Pharmaceuticals
Specifications:

temSpecificationResult
Physical Property
AppearanceWhite crystal powderConforms
OdourCharacteristicConforms
Mesh Size100% through 80% mesh sizeConforms
General Analysis
Identification 
artemisinin
Loss on Drying
Identical to R.S. sample
98%
<5.0%c
Conforms
98.01%
 3.22%
Ash                    ≤5.0%3.37%
Contaminants
Pesticides ResidueMeet USP32<561>Conforms
Lead(Pb)≤3.0mg/kg2.1
Arsenic(As)≤2.0mg/kg1.9
Cadmium(Cd)≤1.0mg/kg0.7
Mercury(Hg)≤0.1mg/kg0.07
Function:
1. With function of controlling of vivax malaria and falciparum malaria symptom, as
well as treatment of chloroquine-resistant strain of insect.
2. With function of oxidant. artemisinin is reduced by catalase,dithiothreitol and
alpha tocopherol.
3. With the function of antibacterial, artemisinin has anti-influenza virus effect.
4. With the function of anti-parasite, artemisinin on the role of anti-schistosomiasis
and leptospirosis.
Application:
1.Artesunate is an antimalarial agent. It is a water-soluble hemisuccinate derivative of dihydroartemisinin.
2.Artemisinin is a sesquiterpene lactone isolated from Artemisia annua, a herb that has traditionally been used in China for the treatment of malaria.
3.Artesunate and its active metabolite dihydroartemisinin are potent blood schizonticides, active against the ring stage of the parasite.
4.Artesunate is ideal for the treatment of severe malaria, including cerebral malaria. It is also active against chloroquine and mefloquine resistant strains of P. falciparum.


my contact infomation is:

Email: cloris_2016@tuskwei.com or

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Website: http://www.tuskwei.net/

Notice: This product is only suitable for laboratory use, or the use of animals. It can not be used directly on the human body

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