Bifonazole is an imidazole antifungal drug. Bifonazole is marketed by Bayer under the trade name Canespor in ointment form. Many other trade names exist.
There are also combinations with carbamide for the treatment of onychomycosis.
Pharmacology
Mechanism of action
Bifonazole has dual mode of action. It inhibits fungal ergosterol biosynthesis at two points, via transformation of 24-methylendihydrolanosterol to desmethylsterol, together with inhibition of HMG-CoA. This enables fungicidal properties against dermatophytes and distinguishes bifonazole from other antifungal drugs.
Pharmacokinetics
Six hours after application, bifonazole concentrations range from 1000 µg/cm³ in the stratum corneum to 5 µg/cm³ in the papillary dermis.
Description
Items
|
Technical index
|
Product name
|
Bifonazole
|
Synonym
|
Mycospor :1-[Phenyl-(4-phenylphenyl)-methyl]imidazole
|
CAS No
|
60628-96-8
|
Melting point
|
C22H18N2
|
Assay
|
98.0-100.5%
|
Ethanol soluble test
|
Qualified
|
Residue on ignition ( as sulfate)
|
0.1% min.
|
Loss on drying
|
0.5% min
|
Function
Topical imidazole antifungal drugs, mainly used for the treatment of various skin ringworm, such as tinea, jock itch, hand, foot and skin ringworm
Application
acute and the chronic skin fungi disease, especially skin hair Tinea bacteria is, small spores bacteria is, Floc epidermal Tinea bacteria; yeast bacteria, as white beads bacteria and the other type of yeast; mold, as song mold due to of skin fungi disease; with chaff-like scales spot mold by caused of spotted bran rash; Rod-like Bacillus due to of Red Tinea; above fungi due to skin shallow table infection.
Specification| Item | Specification | Result |
| Appearance | white to off-white powder | Complies |
| Related substance (HPLC) |
Total impurity ≤0.5%
Max single impurity ≤0.1% |
0.2%
0.06% |
| Odor | Characteristic | Complies |
| Assay | 99% | 99.8% |
| Sieve analysis | 100% pass 80 mesh | Complies |
Loss on Drying
Residue on Ignition |
≤1.0%
≤1.0% |
0.12%
0.09% |
| Heavy Metal | <10ppm | Complies |
| As | <0.1ppm | 0.05ppm |
| Pb | <0.1ppm | 0.05ppm |
| Cd | <0.1ppm | 0.05ppm |
| Residual Solvents | <100ppm | Complies |
| Residual Pesticide | Negative | Complies |
| Microbiology | ||
| Total Plate Count | <1000cfu/g | Complies |
| Yeast & Mold | <100cfu/g | Complies |
| E.Coli | Negative | Complies |
| Salmonella | Negative | Complies |
Packaging & Shipping:
DHL, EMS, TNT, UPS, FEDEX, BY AIR, BY SEA.
DHL Express, Fedex and EMS for quantity less than 50kg, usually called as DUU service.
Sea shipping for quantity over 500kg.
Air shipping is available for 50kg above.
For high value products, please select air shipping and DHL express for safe.
my contact infomation is:
Email: cloris_2016@tuskwei.com or
bettytuskwei@yahoo.com
Skype: betty_3451
Website: http://www.tuskwei.net/
Notice: This product is only suitable for laboratory use, or the use of animals. It can not be used directly on the human body
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