Thiopropamine

Thiopropamine is a stimulant drug which is an analogue of amphetamine where the phenyl ring has been replaced by thiophene. It has similar stimulant effects to amphetamine but with around one third the potency. The N-methyl and thiophen-3-yl analogues are also known and are somewhat more potent, though still generally weaker than the corresponding amphetamines.

Pharmacology

Like amphetamine and most of its analogues, thiopropamine most likely is a norepinephrine-dopamine reuptake inhibitor and/or releasing agent.

Thiopropamine is likely to be metabolized into active 4-hydroxymethiopropamine and thiophene S-oxides. These are further deaminated by CYP2C in liver transforming them into inactive 1-(Thiophen-2-yl)-2-propan-2-one which is a phenylacetone derivative. Propan-2-amines are not metabolized by monoamine oxidases and most actually behave as competitive monoamine oxidase inhibitors.

TECHNICAL INFORMATION

Formal Name	α-methyl-2-thiopheneethanamine, monohydrochloride
CAS Number	53632-92-1
Molecular Formula	C7H11NS • HCl
Formula Weight	177.7
Purity	≥98%
Formulation	A crystalline solid
λmax	233 nm
SMILES	CC(N)CC1=CC=CS1.Cl
InChI Code	1S/C7H11NS.ClH/c1-6(8)5-7-3-2-4-9-7;/h2-4,6H,5,8H2,1H3;1H
InChI Key	MJRDCJBNRNAXIK-UHFFFAOYSA-N

WARNING - This product is not for human or veterinary use.

SHIPPING & STORAGE

Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
Stability	As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly

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Notice: This product is only suitable for laboratory use, or the use of animals. It can not be used directly on the human body