Aliskiren

Aliskiren (trade names Tekturna and Rasilez) is the first in a class of drugs called direct renin inhibitors. Its is used for essential (primary) hypertension. While used for high blood pressure, other better studied medications are typically recommended due to concerns of higher side effects and less evidence of benefit.

Medical uses

While used for high blood pressure, other better studied medications are typically recommended. Prescrire has stated that aliskiren is potentially more harmful than beneficial and thus list it as of 2014 as a drug to avoid.

Mechanism of action

Renin, the first enzyme in the renin–angiotensin–aldosterone system, plays a role in blood pressure control. It cleaves angiotensinogen to angiotensin I, which is in turn converted by angiotensin-converting enzyme (ACE) to angiotensin II. Angiotensin II has both direct and indirect effects on blood pressure. It directly causes arterial smooth muscle to contract, leading to vasoconstriction and increased blood pressure. Angiotensin II also stimulates the production of aldosterone from the adrenal cortex, which causes the tubules of the kidneys to increase reabsorption of sodium, with water following, thereby increasing plasma volume, and thus blood pressure. Aliskiren binds to the S3bp binding site of renin, essential for its activity. Binding to this pocket prevents the conversion of angiotensinogen to angiotensin I. Aliskiren is also available as combination therapy with hydrochlorothiazide.

Introduction: 

Place of orgin : China

CAS No.:173334-57-1

Assay 99%min

Storage ：Store in cool and dry palce. Keep away from strong light ,high temperature.

Usage: Used as pharmaceutical intermediates,Renin inhibitors

transportation：by express delivery (by EMS,DHL,TNT & FEDEX) or sea & air shipping.

Shipment term: EXW, FOB, CIF, CNF

Sample: At any time to provide (lowest price & highest quality)

Certificate of Analysis 

Tests	Specifications	Results
Characters	White to off-white crystalline powder with a characteristic sulfide-like order	Complies
Appearance of solution	Clear and colorless	Complies
Loss on Drying	≤0.5%	0.06%
Sulphated Ash	≤0.2%	0.03%
Heavy metals	≤20PPM	Complies
Moisture	3.0% max	2.3
Assay	98.0% to 99.0%	99.0%

Packaging & Shipping: 

 [Storage] Stored in a clean, cool and dry area; keep away from strong, direct light.

[Shelf Life] 2 years when properly stored.

[Packing]

Inner double plastic bags--25kg/Fiber drum (35*35*53cm, GW: 28kg, NW: 25kg, 0.06CBM);

Inner double plastic bags--5kg/Aluminum foil bag (GW: 6.5kg, NW: 5kg);

Inner double plastic bags--1kg/Aluminum foil bag (GW: 1.5kg, NW: 1kg).

[Delivery] 5 working days after payment.

Shipping

1. Preferentially DHL or FedEx for quantity less than 50KG; Air shipping for 100KG above;

Sea shipping for quantity over 500KG.

2. For customers from Russia, Mexico, Turkey, Slovenia, Romania, etc, before placing an order,

please kindly confirm if you can make clearance when goods reach your customs. 

my contact infomation is:

Email: cloris_2016@tuskwei.com or

bettytuskwei@yahoo.com

Skype: betty_3451

Website: http://www.tuskwei.net/

Notice: This product is only suitable for laboratory use, or the use of animals. It can not be used directly on the human body