Linagliptin

Linagliptin (BI-1356, trade names Tradjenta (US), Trajenta (worldwide)) is a DPP-4 inhibitor developed by Boehringer Ingelheim for treatment of type II diabetes.

Linagliptin (once-daily) was approved by the U.S. Food and Drug Administration (FDA) on 2 May 2011 for treatment of type II diabetes. It is being marketed by Boehringer Ingelheim and Lilly.

Medical uses

Results in 2010 from a Phase III clinical trial of linagliptin showed that the drug can effectively reduce blood sugar.

Mechanism of action

TRADJENTA belongs to a class of drugs called DPP-4 inhibitors. DPP-4 inhibitors work by increasing hormones that stimulate your pancreas to produce more insulin and stimulate your liver to produce less glucose.In other words, TRADJENTA, along with diet and exercise, can help your body produce more insulin and less sugar. Managing your sugar can mean a lower A1C – and that's an important goal for anyone with type 2 diabetes.

products details:

1.Product name: Linagliptin

2.CAS No.:668270-12-0

3.Purity: 99% min

4.Storage information: Store in Cool and dry .place, keep away from strong light, high temperature

5.Usage:Pharmaceutical raw materials

6.Transportation：by air express delivery(DHL,FedEx,EMS ect.) or sea shipping (FOB,CIF,CFR,CNF ect.)

7.Sample：sample can be supplied if you inquiry 

8.Price: we will give you the best price !

Specification:

Product Name	Linagliptin       CAS 668270-12-0
Batch No.	150120		Quantity		25kgs
Test date	2015.01.20		Report date		2015.01.27
Expire date	2017.01.20		Standard		In-house
Result of Analysis
Items		Specifications		Results
Appearance		White or off-white crystalline powder		Conforms
HPLC		The retention time of the major peaking the chromatogram of the sample corresponds to that exhibited by the working standard		Conforms
Loss on drying		No more than 1.0%		0.40%
Residue on Ignition		No more than 0.1%		0.02%
Heavy Metals		No more than 20ppm		<10ppm
Related substances		Total impurities no more than 1.0%		0.50%
		Single impurity no more than 0.5%		Conforms
Residual solvents		Ethyl acetate No more than 0.1%		Conforms
		Ethanol No more than 0.1%		Conforms
Purity		No less than 99.0%		99.50%
Conclusion		Conforms to the In-house standard.

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Notice: This product is only suitable for laboratory use, or the use of animals. It can not be used directly on the human body

Sulbactam

company's website

Sulbactam is a β-lactamase inhibitor. This drug is given in combination with β-lactam antibiotics to inhibit β-lactamase, an enzyme produced by bacteria that destroys the antibiotics.

Mechanism

Sulbactam is an irreversible inhibitor of β-lactamase; it binds to the enzyme and does not allow it to degrade the antibiotic.

Uses

Sulbactam is able to inhibit the most common forms of β-lactamase but is not able to interact with the AmpC cephalosporinase. Thus, it confers little protection against bacteria such as Pseudomonas aeruginosa, Citrobacter, Enterobacter, and Serratia, which often express this gene.

In the United States, sulbactam is combined to form cefoperazone/sulbactam and ampicillin/sulbactam. It does possess some antibacterial activity when administered alone, but it is too weak to have any clinical importance. Its use in the UK is restricted to hospitals.

Recently, its use in treating Acinetobacter septicemia is receiving renewed interest.

Basic information

Product Name:	Sulbactam
Synonyms:	(2S,5R)-3,3-DIMETHYL-4,4,7-TRIOXO-4LAMBDA6-THIA-1-AZA-BICYCLO[3.2.0]HEPTANE-2-CARBOXYLIC ACID;(2S-CIS)-3,3-DIMETHYL-7-OXO-4-THIA-1-AZABICYCLO[3,2,0]HEPTANE-2-CARBOXYLIC ACID 4,4-DIOXIDE;3,3-DIMETHYL-4,4,7-TRIOXO-4LAMBDA6-THIA-1-AZA-BICYCLO[3.2.0]HEPTANE-2-CARBOXYLIC ACID;SULBACTAM;SULBACTAM ACID;sulbactam acid (base);PENICILLANIC ACID SULFONE;(2S,5R)-3,3-Dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide
CAS:	68373-14-8
MF:	C8H11NO5S
MW:	233.24
Product Categories:	Peptide Synthesis/Antibiotics;MERITAL
Mol File:	68373-14-8.mol

Chemical Properties

boiling point	567.7 °C at 760 mmHg
density	1.62 g/cm3
vapor pressure	2.26E-14 mmHg at 25°C
flashing point	297.1 °C
storage temp.	−20°C
solubility	dissolved in water, methanol and ethyl acetate

Specification:

ITEMS	STANDARD	RESULTS
Characters	White or almost white crystalline  granule and powder	A white crystalline granule and powder
Identification	(1)  The  spectrum obtained with the substance to be examined corresponds with that obtained with reference standard (2)  Should meet the requirement under water	Comforms
Appearance of solution	≤reference suspension II (1 mol/L hydrochloric acid) ≤reference suspension II (2 mol/L ammonia)	≤Reference suspension I ≤Reference suspension I
PH	3.5~5.5	4.4
Specific optical rotation	+280~ +305	+296
Related substances	Any impurity≤1.0%	0.26%
Dimethylaniline	≤20ppm	Complies (not used in process)
Water	12.0%~15.0%	13.3%
Sulphated ash	≤0.5%	0.07%
Bulk density	0.45g/ml - 0.65g/ml	0.57g/ml
Tapped density	≥0.65g/ml	0.76g/ml
Assay	96.0%~102.0%  C16H19N3O4S (calculated on the anhydrous basis)	99.7%

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