Delestrogen

Estradiol valerate (EV, E2V) (INN, USAN, JAN) (brand names Progynova, Progynon Depot, Delestrogen, many others), or oestradiol valerate (BAN), is a synthetic, steroidal estrogen and an estrogen ester – specifically, the 17β-valerate ester of estradiol – which is marketed in the United States, Canada, Europe, and throughout much of the rest of the world. It acts as a prodrug of estradiol, and hence, is considered to be a natural, bioidentical form of estrogen. Along with estradiol cypionate, estradiol valerate is one of the most widely used esters of estradiol.

Medical uses

Main article: Estradiol § Medical uses

The medical uses of estradiol valerate are the same as those of estradiol and other estrogens. Examples of indications for the drug include hormone replacement therapy and hormonal contraception. In regards to the latter, estradiol valerate is available in combination with a progestogen as an combined estradiol-containing oral contraceptive (with dienogest) and as a combined injectable contraceptive (with hydroxyprogesterone caproate or norethisterone enanthate).

Pharmacology

The affinity of estradiol valerate for the estrogen receptor is approximately 50 times lower than that of estradiol. In addition, estradiol valerate is rapidly cleaved into estradiol and is unable to reach target tissues in any concentration of significance, if at all. As such, estradiol valerate is essentially inactive in terms of estrogenic effect itself, acting solely as a prodrug to estradiol.

Introduction: 

 Place of orgin : China

Specifications:

CAS no. : 979-32-8

EINECS no. : 213-559-2

Molecular formula: C23H32O3

Molecular weight: 356.4984

Density: 1.13 g/cm3

Melting point: 144 ℃

Boiling point: 486.2 ° C at 760 mmHg

Flash: 191.1 ° C

Vapor pressure: e-10 4.47 mmHg at 25 ° C

Storage ：Store in cool and dry palce. Keep away from strong light ,high temperature.

Usage: Used to treat amenorrhea, menopausal syndrome, reduce milk secretion, prostate cancer, etc

transportation：by express delivery (by EMS,DHL,TNT & FEDEX) or sea & air shipping. 

Shipment term: EXW, FOB, CIF, CNF

Sample: At any time to provide (lowest price & highest quality)

Product name	Estradiol valerate
Appearance	White crystalline powder
Water	≤3.5%	pass
Assay	97 .0~ 103.0%	99.2%
Loss on drying	≤0.5%	0.17%
Related substances	total impurities ≤1.0%	Pass
	any individual impurity ≤0.5%	Pass
Residual solvents	ethanol ≤0.5%	Pass

my contact infomation is:
Email: bettyapi@aliyun.com or bettyapi1989@yahoo.com
Skype: bettyapi1989

Notice: This product is only suitable for laboratory use, or the use of animals. It can not be used directly on the human body

Progynon Depot

Estradiol valerate (EV, E2V) (INN, USAN, JAN) (brand names Progynova, Progynon Depot, Delestrogen, many others), or oestradiol valerate (BAN), is a synthetic, steroidal estrogen and an estrogen ester – specifically, the 17β-valerate ester of estradiol – which is marketed in the United States, Canada, Europe, and throughout much of the rest of the world. It acts as a prodrug of estradiol, and hence, is considered to be a natural, bioidentical form of estrogen. Along with estradiol cypionate, estradiol valerate is one of the most widely used esters of estradiol.

Medical uses

Main article: Estradiol § Medical uses

The medical uses of estradiol valerate are the same as those of estradiol and other estrogens. Examples of indications for the drug include hormone replacement therapy and hormonal contraception. In regards to the latter, estradiol valerate is available in combination with a progestogen as an combined estradiol-containing oral contraceptive (with dienogest) and as a combined injectable contraceptive (with hydroxyprogesterone caproate or norethisterone enanthate).

Pharmacology

The affinity of estradiol valerate for the estrogen receptor is approximately 50 times lower than that of estradiol. In addition, estradiol valerate is rapidly cleaved into estradiol and is unable to reach target tissues in any concentration of significance, if at all. As such, estradiol valerate is essentially inactive in terms of estrogenic effect itself, acting solely as a prodrug to estradiol.

Introduction: 

 Place of orgin : China

Specifications:

CAS no. : 979-32-8

EINECS no. : 213-559-2

Molecular formula: C23H32O3

Molecular weight: 356.4984

Density: 1.13 g/cm3

Melting point: 144 ℃

Boiling point: 486.2 ° C at 760 mmHg

Flash: 191.1 ° C

Vapor pressure: e-10 4.47 mmHg at 25 ° C

Storage ：Store in cool and dry palce. Keep away from strong light ,high temperature.

Usage: Used to treat amenorrhea, menopausal syndrome, reduce milk secretion, prostate cancer, etc

transportation：by express delivery (by EMS,DHL,TNT & FEDEX) or sea & air shipping. 

Shipment term: EXW, FOB, CIF, CNF

Sample: At any time to provide (lowest price & highest quality)

Product name	Estradiol valerate
Appearance	White crystalline powder
Water	≤3.5%	pass
Assay	97 .0~ 103.0%	99.2%
Loss on drying	≤0.5%	0.17%
Related substances	total impurities ≤1.0%	Pass
	any individual impurity ≤0.5%	Pass
Residual solvents	ethanol ≤0.5%	Pass

my contact infomation is:
Email: bettyapi@aliyun.com or bettyapi1989@yahoo.com
Skype: bettyapi1989

Notice: This product is only suitable for laboratory use, or the use of animals. It can not be used directly on the human body

Progynova

Estradiol valerate (EV, E2V) (INN, USAN, JAN) (brand names Progynova, Progynon Depot, Delestrogen, many others), or oestradiol valerate (BAN), is a synthetic, steroidal estrogen and an estrogen ester – specifically, the 17β-valerate ester of estradiol – which is marketed in the United States, Canada, Europe, and throughout much of the rest of the world. It acts as a prodrug of estradiol, and hence, is considered to be a natural, bioidentical form of estrogen. Along with estradiol cypionate, estradiol valerate is one of the most widely used esters of estradiol.

Medical uses

Main article: Estradiol § Medical uses

The medical uses of estradiol valerate are the same as those of estradiol and other estrogens. Examples of indications for the drug include hormone replacement therapy and hormonal contraception. In regards to the latter, estradiol valerate is available in combination with a progestogen as an combined estradiol-containing oral contraceptive (with dienogest) and as a combined injectable contraceptive (with hydroxyprogesterone caproate or norethisterone enanthate).

Pharmacology

The affinity of estradiol valerate for the estrogen receptor is approximately 50 times lower than that of estradiol. In addition, estradiol valerate is rapidly cleaved into estradiol and is unable to reach target tissues in any concentration of significance, if at all. As such, estradiol valerate is essentially inactive in terms of estrogenic effect itself, acting solely as a prodrug to estradiol.

Introduction: 

 Place of orgin : China

Specifications:

CAS no. : 979-32-8

EINECS no. : 213-559-2

Molecular formula: C23H32O3

Molecular weight: 356.4984

Density: 1.13 g/cm3

Melting point: 144 ℃

Boiling point: 486.2 ° C at 760 mmHg

Flash: 191.1 ° C

Vapor pressure: e-10 4.47 mmHg at 25 ° C

Storage ：Store in cool and dry palce. Keep away from strong light ,high temperature.

Usage: Used to treat amenorrhea, menopausal syndrome, reduce milk secretion, prostate cancer, etc

transportation：by express delivery (by EMS,DHL,TNT & FEDEX) or sea & air shipping. 

Shipment term: EXW, FOB, CIF, CNF

Sample: At any time to provide (lowest price & highest quality)

Product name	Estradiol valerate
Appearance	White crystalline powder
Water	≤3.5%	pass
Assay	97 .0~ 103.0%	99.2%
Loss on drying	≤0.5%	0.17%
Related substances	total impurities ≤1.0%	Pass
	any individual impurity ≤0.5%	Pass
Residual solvents	ethanol ≤0.5%	Pass

my contact infomation is:
Email: bettyapi@aliyun.com or bettyapi1989@yahoo.com
Skype: bettyapi1989

Notice: This product is only suitable for laboratory use, or the use of animals. It can not be used directly on the human body

oestradiol valerate

Estradiol valerate (EV, E2V) (INN, USAN, JAN) (brand names Progynova, Progynon Depot, Delestrogen, many others), or oestradiol valerate (BAN), is a synthetic, steroidal estrogen and an estrogen ester – specifically, the 17β-valerate ester of estradiol – which is marketed in the United States, Canada, Europe, and throughout much of the rest of the world. It acts as a prodrug of estradiol, and hence, is considered to be a natural, bioidentical form of estrogen. Along with estradiol cypionate, estradiol valerate is one of the most widely used esters of estradiol.

Medical uses

Main article: Estradiol § Medical uses

The medical uses of estradiol valerate are the same as those of estradiol and other estrogens. Examples of indications for the drug include hormone replacement therapy and hormonal contraception. In regards to the latter, estradiol valerate is available in combination with a progestogen as an combined estradiol-containing oral contraceptive (with dienogest) and as a combined injectable contraceptive (with hydroxyprogesterone caproate or norethisterone enanthate).

Pharmacology

The affinity of estradiol valerate for the estrogen receptor is approximately 50 times lower than that of estradiol. In addition, estradiol valerate is rapidly cleaved into estradiol and is unable to reach target tissues in any concentration of significance, if at all. As such, estradiol valerate is essentially inactive in terms of estrogenic effect itself, acting solely as a prodrug to estradiol.

Introduction: 

 Place of orgin : China

Specifications:

CAS no. : 979-32-8

EINECS no. : 213-559-2

Molecular formula: C23H32O3

Molecular weight: 356.4984

Density: 1.13 g/cm3

Melting point: 144 ℃

Boiling point: 486.2 ° C at 760 mmHg

Flash: 191.1 ° C

Vapor pressure: e-10 4.47 mmHg at 25 ° C

Storage ：Store in cool and dry palce. Keep away from strong light ,high temperature.

Usage: Used to treat amenorrhea, menopausal syndrome, reduce milk secretion, prostate cancer, etc

transportation：by express delivery (by EMS,DHL,TNT & FEDEX) or sea & air shipping. 

Shipment term: EXW, FOB, CIF, CNF

Sample: At any time to provide (lowest price & highest quality)

Product name	Estradiol valerate
Appearance	White crystalline powder
Water	≤3.5%	pass
Assay	97 .0~ 103.0%	99.2%
Loss on drying	≤0.5%	0.17%
Related substances	total impurities ≤1.0%	Pass
	any individual impurity ≤0.5%	Pass
Residual solvents	ethanol ≤0.5%	Pass

my contact infomation is:
Email: bettyapi@aliyun.com or bettyapi1989@yahoo.com
Skype: bettyapi1989

Notice: This product is only suitable for laboratory use, or the use of animals. It can not be used directly on the human body

Estradiol valerate

Estradiol valerate (EV, E2V) (INN, USAN, JAN) (brand names Progynova, Progynon Depot, Delestrogen, many others), or oestradiol valerate (BAN), is a synthetic, steroidal estrogen and an estrogen ester – specifically, the 17β-valerate ester of estradiol – which is marketed in the United States, Canada, Europe, and throughout much of the rest of the world. It acts as a prodrug of estradiol, and hence, is considered to be a natural, bioidentical form of estrogen. Along with estradiol cypionate, estradiol valerate is one of the most widely used esters of estradiol.

Medical uses

Main article: Estradiol § Medical uses

The medical uses of estradiol valerate are the same as those of estradiol and other estrogens. Examples of indications for the drug include hormone replacement therapy and hormonal contraception. In regards to the latter, estradiol valerate is available in combination with a progestogen as an combined estradiol-containing oral contraceptive (with dienogest) and as a combined injectable contraceptive (with hydroxyprogesterone caproate or norethisterone enanthate).

Pharmacology

The affinity of estradiol valerate for the estrogen receptor is approximately 50 times lower than that of estradiol. In addition, estradiol valerate is rapidly cleaved into estradiol and is unable to reach target tissues in any concentration of significance, if at all. As such, estradiol valerate is essentially inactive in terms of estrogenic effect itself, acting solely as a prodrug to estradiol.

Introduction: 

 Place of orgin : China

Specifications:

CAS no. : 979-32-8

EINECS no. : 213-559-2

Molecular formula: C23H32O3

Molecular weight: 356.4984

Density: 1.13 g/cm3

Melting point: 144 ℃

Boiling point: 486.2 ° C at 760 mmHg

Flash: 191.1 ° C

Vapor pressure: e-10 4.47 mmHg at 25 ° C

Storage ：Store in cool and dry palce. Keep away from strong light ,high temperature.

Usage: Used to treat amenorrhea, menopausal syndrome, reduce milk secretion, prostate cancer, etc

transportation：by express delivery (by EMS,DHL,TNT & FEDEX) or sea & air shipping. 

Shipment term: EXW, FOB, CIF, CNF

Sample: At any time to provide (lowest price & highest quality)

Product name	Estradiol valerate
Appearance	White crystalline powder
Water	≤3.5%	pass
Assay	97 .0~ 103.0%	99.2%
Loss on drying	≤0.5%	0.17%
Related substances	total impurities ≤1.0%	Pass
	any individual impurity ≤0.5%	Pass
Residual solvents	ethanol ≤0.5%	Pass

my contact infomation is:
Email: bettyapi@aliyun.com or bettyapi1989@yahoo.com
Skype: bettyapi1989

Notice: This product is only suitable for laboratory use, or the use of animals. It can not be used directly on the human body

estradiol heptanoate

Estradiol enanthate (INN, USAN), or estradiol heptanoate, is a synthetic, steroidal estrogen and an estrogen ester – specifically, the 17β-enanthate ester of estradiol – which is used as a component of hormonal contraception. It acts as a prodrug of estradiol, and hence, is considered to be a natural, bioidentical form of estrogen. Estradiol enanthate is used in combination with the progestogen dihydroxyprogesterone acetophenide as a once-monthly combined injectable contraceptive in Spain and Latin America under brand names including Anafertin, Deladroxate, Perlutan, and Topasel. This combination has been marketed since the mid-1960s.Estradiol enanthate does not appear to be available as a standalone drug (i.e., by itself).

When estradiol enanthate is administered in oil via intramuscular injection, a depot effect occurs, and the drug has a very long duration of effect. A single 10 mg intramuscular dose of estradiol enanthate has been found to result in significantly elevated levels of estradiol for at least 31 days.The duration of estradiol enanthate is considerably longer than that of various other commonly used estradiol esters like estradiol valerate and estradiol cypionate.

Product Detailed

Superlist Name: Estradiol Enanthate99%

Formula: C25H36O3

Synonyms: Estradiol,17-heptanoate (6CI,7CI,8CI);Heptanoic acid, 3-hydroxyestra-1,3,5(10)-trien-17b-yl ester (8CI);Estradiol17-enanthate;Estradiol enanthate;SQ 16150;Estra-1,3,5(10)-triene-3,17-diol(17b)-, 17-heptanoate;

Molecular Weight: 384.55

EINECS: 225-599-8

CAS No.: 4956-37-0

Boiling Point: 509.5 °C at 760 mmHg

Flash Point: 197.1 °C

Appearance: white powder

Risk Codes: 20/21/22-40

Safety: 22-36

Transport Information: By Sea,by Air,By courier like DHL or Fedx.

Package: 10G/pack,100g/pack,1kg/pack (aluminium foil bag)

Storage：2 year

Sample: we provide free sample.

Delivery:3days by EMS,FEDEX,DHL.

Specification:

my contact infomation is: 
Email: bettyapi@aliyun.com or bettyapi1989@yahoo.com
Skype: bettyapi1989

Notice: This product is only suitable for laboratory use, or the use of animals. It can not be used directly on the human body

Estradiol enanthate

Estradiol enanthate (INN, USAN), or estradiol heptanoate, is a synthetic, steroidal estrogen and an estrogen ester – specifically, the 17β-enanthate ester of estradiol – which is used as a component of hormonal contraception. It acts as a prodrug of estradiol, and hence, is considered to be a natural, bioidentical form of estrogen. Estradiol enanthate is used in combination with the progestogen dihydroxyprogesterone acetophenide as a once-monthly combined injectable contraceptive in Spain and Latin America under brand names including Anafertin, Deladroxate, Perlutan, and Topasel. This combination has been marketed since the mid-1960s.Estradiol enanthate does not appear to be available as a standalone drug (i.e., by itself).

When estradiol enanthate is administered in oil via intramuscular injection, a depot effect occurs, and the drug has a very long duration of effect. A single 10 mg intramuscular dose of estradiol enanthate has been found to result in significantly elevated levels of estradiol for at least 31 days.The duration of estradiol enanthate is considerably longer than that of various other commonly used estradiol esters like estradiol valerate and estradiol cypionate.

Product Detailed

Superlist Name: Estradiol Enanthate99%

Formula: C25H36O3

Synonyms: Estradiol,17-heptanoate (6CI,7CI,8CI);Heptanoic acid, 3-hydroxyestra-1,3,5(10)-trien-17b-yl ester (8CI);Estradiol17-enanthate;Estradiol enanthate;SQ 16150;Estra-1,3,5(10)-triene-3,17-diol(17b)-, 17-heptanoate;

Molecular Weight: 384.55

EINECS: 225-599-8

CAS No.: 4956-37-0

Boiling Point: 509.5 °C at 760 mmHg

Flash Point: 197.1 °C

Appearance: white powder

Risk Codes: 20/21/22-40

Safety: 22-36

Transport Information: By Sea,by Air,By courier like DHL or Fedx.

Package: 10G/pack,100g/pack,1kg/pack (aluminium foil bag)

Storage：2 year

Sample: we provide free sample.

Delivery:3days by EMS,FEDEX,DHL.

Specification:

my contact infomation is: 
Email: bettyapi@aliyun.com or bettyapi1989@yahoo.com
Skype: bettyapi1989

Notice: This product is only suitable for laboratory use, or the use of animals. It can not be used directly on the human body

19-normegestrol

Nomegestrol (INN), also known as 19-normegestrol, is a steroidal progestin which was patented in 1975 but was never marketed. It is the parent compound of nomegestrol acetate, which is marketed as a progestin.

Introduction:

Production name: Nomegestrol 58691-88-6

Cas no.: 58691-88-6

Purity: 99% min

MF: C21H28O3

Nomegestrol 58691-88-6

Name: Nomegestrol 58691-88-6

Synonyms: 17-Hydroxy-6-methyl-19-nor-4,6-pregnadiene-3,20-dione

Molecular Formula: C21H28O3

Molecular Weight:  328.45

CAS Registry Number:  58691-88-6

Specifications:

Spec.:99% of Nomegestrol Powder

Analysis Test	Specification	Result
Description	White crystalline powder,odorless	Conforms
Solubility	Easily soluble in water, unsoluble in ethanol	Conforms
PH	6.0~7.5	6.9
Solution clarity and color	solution should be clear and colorless	Conforms
Related substances	5’CMP 0.3% Simple impurity Total other impurity	0.01% 0.03% 0.10%
Chloride	0.05%	Conforms
Ammonium	0.05%	Conforms
Fe	0.01%	Conforms
Phosphate	0.1%	Conforms
Loss on drying	≤6.0%	1.3%
Heavy metals	0.002%	Conforms
Arsenide	0.0001%	Conforms
Bacterial Endotoxins	0.3EU/mg	Conforms
Microbial Limit	Conforms	Conforms
Assay(on dried basis)	≥98.0%	98.8%
Conclusion: The results conform with CP2013

my contact infomation is:
Email: bettyapi@aliyun.com or bettyapi1989@yahoo.com
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Whatapp: 008613739707029

Notice: This product is only suitable for laboratory use, or the use of animals. It can not be used directly on the human body

Nomegestrol (INN)

Nomegestrol (INN), also known as 19-normegestrol, is a steroidal progestin which was patented in 1975 but was never marketed. It is the parent compound of nomegestrol acetate, which is marketed as a progestin.

Introduction:

Production name: Nomegestrol 58691-88-6

Cas no.: 58691-88-6

Purity: 99% min

MF: C21H28O3

Nomegestrol 58691-88-6

Name: Nomegestrol 58691-88-6

Synonyms: 17-Hydroxy-6-methyl-19-nor-4,6-pregnadiene-3,20-dione

Molecular Formula: C21H28O3

Molecular Weight:  328.45

CAS Registry Number:  58691-88-6

Specifications:

Spec.:99% of Nomegestrol Powder

Analysis Test	Specification	Result
Description	White crystalline powder,odorless	Conforms
Solubility	Easily soluble in water, unsoluble in ethanol	Conforms
PH	6.0~7.5	6.9
Solution clarity and color	solution should be clear and colorless	Conforms
Related substances	5’CMP 0.3% Simple impurity Total other impurity	0.01% 0.03% 0.10%
Chloride	0.05%	Conforms
Ammonium	0.05%	Conforms
Fe	0.01%	Conforms
Phosphate	0.1%	Conforms
Loss on drying	≤6.0%	1.3%
Heavy metals	0.002%	Conforms
Arsenide	0.0001%	Conforms
Bacterial Endotoxins	0.3EU/mg	Conforms
Microbial Limit	Conforms	Conforms
Assay(on dried basis)	≥98.0%	98.8%
Conclusion: The results conform with CP2013

 

my contact infomation is:
Email: bettyapi@aliyun.com or bettyapi1989@yahoo.com
Skype: bettyapi1989
Whatapp: 008613739707029

Notice: This product is only suitable for laboratory use, or the use of animals. It can not be used directly on the human body

(17β)-estra-1,3,5(10)-triene-3,17diol

Estradiol (E2), also spelled oestradiol, is a steroid, an estrogen, and the primary female sex hormone. It is named for and is important in the regulation of the estrous and menstrual female reproductive cycles. Estradiol is essential for the development and maintenance of female reproductive tissues such as the breasts, uterus, and vagina during puberty, adulthood, and pregnancy, but it also has important effects in many other tissues including bone, fat, skin, liver, and the brain. While estrogen levels in men are lower compared to women, estrogens have essential functions in men as well. Estradiol is found in most vertebrates as well as many crustaceans, insects, fish, and other animal species.

 

Estradiol is produced especially within the follicles of the female ovaries, but also in other endocrine (i.e., hormone-producing) and non-endocrine tissues (e.g., including fat, liver, adrenal, breast, and neural tissues). Estradiol is biosynthesized from cholesterol through a series of chemical intermediates. One principal pathway involves the generation of 4-androstenedione, which is converted into estrone by aromatase and then by 17β-hydroxysteroid dehydrogenase into estradiol. Alternatively, 4-androstenedione can be converted into testosterone, an androgen and the primary male sex hormone, which in turn can be aromatized into estradiol.

 

Medical uses

 

Main article: Estradiol (medication)

Estradiol is used as a medication, mainly in hormone replacement therapy.

 

Chemistry

 

Estradiol is an estrane (C18) steroid. It is also known as 17β-estradiol (to distinguish it from 17α-estradiol) or as estra-1,3,5(10)-triene-3,17β-diol. It has two hydroxyl groups, one at the C3 position and the other at the 17β position, as well as three double bonds in the A ring. Due to its two hydroxyl groups, estradiol is often abbreviated as E2. The structurally related estrogens, estrone (E1), estriol (E3), and estetrol (E4) have one, three, and four hydroxyl groups, respectively.

 

Details: 

 

1. Product Name: Estradiol

Synonyms: BETA-ESTRADIOL-16,16,17-D3;17BETA-ESTRADIOL-16,16,17-D3;(+)-3,17β-estradiol;(17b)-estra-1,3,5(10)-triene-3,17diol;(17β)-estra-1,3,5(10)-triene-3,17diol;.alpha.-Oestradiol;.beta.-Oestradiol;17-.beta.-Estra-1,3,5(10)-triene-3,17-diol

CAS: 50-28-2

MF: C18H24O2

MW: 272.38

EINECS: 200-023-8

Product Categories: Steroids;Estrogen;Hormone;Analytical Chemistry;Biochemistry;Environmental Endocrine Disruptors;Estradiol, etc. (Environmental Endocrine Disruptors);Hydroxysteroids;Intracellular receptor;Intermediates & Fine Chemicals;Pharmaceuticals;Steroid and Hormone;API;VIVELLE;Hormone Drugs

mp 178-179 °C(lit.)

refractive index 80.4 ° (C=1, Dioxane)

storage temp. 2-8°C

form powder

Merck 14,3703

BRN 1914275

Stability: Stable. Incompatible with strong oxidizing agents.

Chemical Properties White Crystalline Powder

Usage : Potent mammalian estrogenic hormone produced by the ovary.

Estradiol is the major estrogen secreted by the premenopausal ovary.

 

 

2. COA:

 

Product name Estradiol

Appearance White crystaline powder

Characteristics White or creamy white, crystaline powder conform

Melting point 173 ~ 179°C 178~ 179°C

Specific rotation +76°~+83° +78.5°

Water ≤3.5% pass

Assay 97 .0~ 103.0% 99.07%

Loss on drying ≤0.5% 0.21%

Related substances total impurities ≤1.0% Pass

any individual impurity ≤0.5% Pass

Residual solvents ethanol ≤0.5% Pass

Payment:

Western Union, MoneyGram,BitCoin,Bank transfer ect.

Shipment:

TNT, UPS, DHL, FEDEX, EMS or Client's request

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Skype: bettyapi1989
Whatapp: 008613739707029

Notice: This product is only suitable for laboratory use, or the use of animals. It can not be used directly on the human body

17BETA-ESTRADIOL-16,16,17-D3;

Estradiol (E2), also spelled oestradiol, is a steroid, an estrogen, and the primary female sex hormone. It is named for and is important in the regulation of the estrous and menstrual female reproductive cycles. Estradiol is essential for the development and maintenance of female reproductive tissues such as the breasts, uterus, and vagina during puberty, adulthood, and pregnancy, but it also has important effects in many other tissues including bone, fat, skin, liver, and the brain. While estrogen levels in men are lower compared to women, estrogens have essential functions in men as well. Estradiol is found in most vertebrates as well as many crustaceans, insects, fish, and other animal species.

 

Estradiol is produced especially within the follicles of the female ovaries, but also in other endocrine (i.e., hormone-producing) and non-endocrine tissues (e.g., including fat, liver, adrenal, breast, and neural tissues). Estradiol is biosynthesized from cholesterol through a series of chemical intermediates. One principal pathway involves the generation of 4-androstenedione, which is converted into estrone by aromatase and then by 17β-hydroxysteroid dehydrogenase into estradiol. Alternatively, 4-androstenedione can be converted into testosterone, an androgen and the primary male sex hormone, which in turn can be aromatized into estradiol.

 

Medical uses

 

Main article: Estradiol (medication)

Estradiol is used as a medication, mainly in hormone replacement therapy.

 

Chemistry

 

Estradiol is an estrane (C18) steroid. It is also known as 17β-estradiol (to distinguish it from 17α-estradiol) or as estra-1,3,5(10)-triene-3,17β-diol. It has two hydroxyl groups, one at the C3 position and the other at the 17β position, as well as three double bonds in the A ring. Due to its two hydroxyl groups, estradiol is often abbreviated as E2. The structurally related estrogens, estrone (E1), estriol (E3), and estetrol (E4) have one, three, and four hydroxyl groups, respectively.

 

Details: 

 

1. Product Name: Estradiol

Synonyms: BETA-ESTRADIOL-16,16,17-D3;17BETA-ESTRADIOL-16,16,17-D3;(+)-3,17β-estradiol;(17b)-estra-1,3,5(10)-triene-3,17diol;(17β)-estra-1,3,5(10)-triene-3,17diol;.alpha.-Oestradiol;.beta.-Oestradiol;17-.beta.-Estra-1,3,5(10)-triene-3,17-diol

CAS: 50-28-2

MF: C18H24O2

MW: 272.38

EINECS: 200-023-8

Product Categories: Steroids;Estrogen;Hormone;Analytical Chemistry;Biochemistry;Environmental Endocrine Disruptors;Estradiol, etc. (Environmental Endocrine Disruptors);Hydroxysteroids;Intracellular receptor;Intermediates & Fine Chemicals;Pharmaceuticals;Steroid and Hormone;API;VIVELLE;Hormone Drugs

mp 178-179 °C(lit.)

refractive index 80.4 ° (C=1, Dioxane)

storage temp. 2-8°C

form powder

Merck 14,3703

BRN 1914275

Stability: Stable. Incompatible with strong oxidizing agents.

Chemical Properties White Crystalline Powder

Usage : Potent mammalian estrogenic hormone produced by the ovary.

Estradiol is the major estrogen secreted by the premenopausal ovary.

 

 

2. COA:

 

Product name Estradiol

Appearance White crystaline powder

Characteristics White or creamy white, crystaline powder conform

Melting point 173 ~ 179°C 178~ 179°C

Specific rotation +76°~+83° +78.5°

Water ≤3.5% pass

Assay 97 .0~ 103.0% 99.07%

Loss on drying ≤0.5% 0.21%

Related substances total impurities ≤1.0% Pass

any individual impurity ≤0.5% Pass

Residual solvents ethanol ≤0.5% Pass

Payment:

Western Union, MoneyGram,BitCoin,Bank transfer ect.

Shipment:

TNT, UPS, DHL, FEDEX, EMS or Client's request

my contact infomation is:
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Notice: This product is only suitable for laboratory use, or the use of animals. It can not be used directly on the human body