Dutasteride

Dutasteride, sold under the brand name Avodart among others, is a medication used to treat benign prostatic hyperplasia (enlarged prostate) and androgenetic alopecia (pattern hair loss).

It was developed by GlaxoSmithKlineand is a 5α-reductase inhibitor which prevents the conversion of the androgen sex hormone testosterone into the more potent dihydrotestosterone (DHT). The drug has been licensed for the treatment of androgenetic alopecia in South Korea since 2009, but has not been approved for this indication in the United States, though it is commonly used off-label.

Medical uses

Avodart (dutasteride) 500 µg soft capsules

Prostate enlargement

Dutasteride is useful for treating benign prostatic hyperplasia (BPH); colloquially known as an "enlarged prostate".

Prostate cancer

In those who are being regularly screened, 5α-reductase inhibitors such as finasteride and dutasteride reduce the overall risk of being diagnosed with prostate cancer; however, there is insufficient data to determine if they have an effect on the risk of death and may increase the chance of more serious cases.

Pattern hair loss

Dutasteride is approved for the treatment of male androgenetic alopecia in South Korea at a dosage of 0.5 mg per day. It has been found in several studies to improve hair growth in men more rapidly and to a greater extent than 2.5 mg/day finasteride.Dutasteride has also been used off-label in the treatment of female pattern hair loss.

CAS Number:164656-23-9

Name:Dutasteride

Formula:C27H30F6N2O2

Molecular Weight:528.53

Synonyms:Avodart;5'-xylidide

Density:1.303 g/cm3

Melting Point:242-250 °C

Boiling Point:620.3 °C at 760 mmHg

Flash Point:329 °C

Solubility:soluble in ethanol (44 mg/mL), methanol (64 mg/mL) and polyethylene glycol 400 (3 mg/mL),

but it is insoluble in water

Appearance:white crystalline solid

AvailableForms:powder

Storage:Normal Conditions

Assay:99%min

Appearance:White to yellowish powder

Package:as customer request

Specification:

Contents of testing	Specifications	Results
Appearance	White or off-white crystalline powder	Complies
Solubility	Soluble in dichloromethane, slightly soluble in ethyl acetate,  methanol, acetronile,  insoluble in water	Complies
Identification (IR)	Should match with working standard	Complies
Melting point	246.0°C~252.0°C	248.0°C~249.5°C
Water by KF	Not more than 0.5%	0.05%
Loss on drying	Not more than 0.5%	0.03%
Residue on ignition %	Not more than 0.2%	0.05%
Heavy  metal	Not more than 20 ppm	Complies
Related Substances(HPLC)
Single maximum impurity	Not more than 0.5%	0.31%
Total impurities	Not more than 1.0%	0.64%
Assay(HPLC,Base on drying) %	98.0%-102.0%	99.24%
Conclusion:	Conform with our Enterprise Standard

Packaging & Shipping:

Packaging:

1g/bag, 100g/bag, 1kg/bag, 25kg/drum

or other quantity just as you requests.

Shipping methods:

We offer several delivery services to suit all customer needs, such as AIR freight, DHL, FEDEX, TNT, UPS, EMS, SEA freight and others.

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Notice: This product is only suitable for laboratory use, or the use of animals. It can not be used directly on the human body